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National efforts to develop a coronavirus disease 2019 (COVID-19) vaccine at “warp speed” will likely yield a safe and effective vaccine by early 2021. However, this important milestone is only the first step in an equally important challenge: getting a majority of the US public vaccinated. In a September 2020 survey of 10 093 US adults, only 51% indicated that they were definitely or probably willing to be vaccinated with a novel COVID-19 vaccine, 25% reported that they were probably not willing to get the vaccine, and 24% reported that it is unlikely that they would be vaccinated.