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Application of air-cleaning devices may be a useful strategy to reduce airborne transmission risks in poorly ventilated spaces (medium confidence). Air cleaning devices have limited benefit in spaces that are already adequately ventilated, and are not necessary for adequately ventilated buildings unless there are identified specific risks (medium confidence).
Air cleaning devices are not a substitute for ventilation, and should never be used as a reason to reduce ventilation; all occupied spaces must have some background ventilation to be suitable for human habitation and to comply with building and workplace regulations. Ventilation should be assessed, and if possible improved, first before considering whether there is a need to use an air cleaner (high confidence).