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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), genus Betacoronavirus, subgenus Sarbecovirus, family Coronaviridae, is a positive-polarity single-stranded RNA virus that probably originated in bats and is the causative agent of coronavirus disease of 2019 (COVID-19). The dynamics of the COVID-19 pandemic have proven to be complex. Many challenges remain pertaining to a better understanding of the epidemiology, pathology, and transmission of COVID-19. For example, the clinical manifestations of COVID-19 range from an asymptomatic infection, mild respiratory illness to pneumonia, respiratory failure, multi-organ failure, and death. Diarrhea due to gastro-intestinal infection can also occur, and in vitro modeling suggests that the virus infects human gut enterocytes. SARS-CoV-2 RNA can be found in rectal swabs and fecal aerosols, even after nasal-pharyngeal testing has turned negative, suggesting that a fecal-oral transmission route may be possible.